NAFLD IN WISTAR RATS AFTER FRUCTOSE CONSUMPTION - ULTRASOUND, BIOCHEMICAL AND HISTOLOGICAL CHANGES
The aim of the study was to model hepatic steatosis as a manifestation of metabolicÂ syndrome in male Wistar rats after an 8-week administration of 15% fructose.Â Ultrasonographic evaluation of the experimental group showed evidence of non-alcoholicÂ fatty liver disease (NAFLD). Alanine aminotransferase (ALT), aspartate aminotransferaseÂ (AST) and uric acid were significantly elevated in sera from the treated rats. HistologicalÂ examination found development of hepatic steatosis in rats of the fructose groupÂ compared with controls. The current study showed the risk associated with fructoseÂ overconsumption in food and beverages for the development of metabolic syndrome andÂ related fatty liver disease, gout, type 2 diabetes, arterial hypertension and other disorders.