NAFLD IN WISTAR RATS AFTER FRUCTOSE CONSUMPTION - ULTRASOUND, BIOCHEMICAL AND HISTOLOGICAL CHANGES

Authors

  • Gergana Sandeva Trakia University, Stara Zagora
  • Rositsa Sandeva Trakia University, Stara Zagora
  • Vanya Tsoneva University Hospital, Stara Zagora
  • Krasimira Nancheva-Koleva University Hospital, Stara Zagora
  • Maya Gulubova Trakia University, Stara Zagora

Abstract

The aim of the study was to model hepatic steatosis as a manifestation of metabolic syndrome in male Wistar rats after an 8-week administration of 15% fructose. Ultrasonographic evaluation of the experimental group showed evidence of non-alcoholic fatty liver disease (NAFLD). Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and uric acid were significantly elevated in sera from the treated rats. Histological examination found development of hepatic steatosis in rats of the fructose group compared with controls. The current study showed the risk associated with fructose overconsumption in food and beverages for the development of metabolic syndrome and related fatty liver disease, gout, type 2 diabetes, arterial hypertension and other disorders.

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Published

2015-12-26