THE OPTIMIZATION OF THE FORMULATION AND PRODUCTION BY EXTRUSION-SPHERONIZATION OF INERT PELLETS BASED ON MICROCRYSTALINE CELULOSE AND LACTOSE

Authors

  • Mircea Hirjau Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila"
  • Alina Ortan Department of Mathematics, Physics and Terrestrial Measurements, Faculty of Land Reclamation and Environmental Engineering, University of Agronomical Sciences and Veterinary Medicine
  • Alexandru Calin Department of Mathematics, Physics and Terrestrial Measurements, Faculty of Land Reclamation and Environmental Engineering, University of Agronomical Sciences and Veterinary Medicine
  • Cristina Elena Dinu Pirvu Department of Physical and Colloid Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila"

Abstract

The "design of experiment" approach to the manufacture of a product allows the
simultaneous study of formulation and process variables that significantly influence the quality of a finished product, by performing only a limited number of experiments. The aim of this study was to use design of experiment in order to optimize the laboratoryscale production by extrusion-spheronization of inert pellet cores consisting of a completely biodegradable, binary mixture of microcrystalline cellulose (MCC) and lactose (L). We have established the exact proportion of MCC, L and binder solution (a 2.5 % solution of polyvinylpyrrolidone, Kollidon K29/32 in water) and process variables (spheronization time and speed) required for the production of pellets with desired, known, preset characteristics, such as size distribution, circularity and flow behavior.

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Published

2015-12-22

Issue

Section

Working Group 1: Plant Cultivation and Animal Growing Technologies