THE STUDY OF PARTITION COEFFICIENT OCTANOL/WATER FOR 3-(2-ALCHYLSULFANYL-6-BENZOTHIAZOLYLAMINOMETHYL)-2- BENZOXAZOLTIONE AS PHOTOSYNTHESIS INHIBITORS

Authors

  • Emilia Amzoiu Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova
  • Ionela Belu Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova
  • Larisa Elisabeth Averis Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova
  • Denisa Amzoiu Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova
  • Ludovic Bejenaru Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova

Abstract

It is well known that  benzoxazole derivatives have a wide range of biological activities. Recently, it was shown that the derivatives of benzoxazoltione, substituted at an amino group inhibit photosynthesis in chloroplasts and algae such as Chlorela vulgaris. It was observed that the inhibitory effect decreases with increasing lipophilicity of substances in the series. The lipophilicity or hydrophilicity are expressed by the partition coefficient, which is a very important factor that characterize the pharmacokinetic profile of a chemical compound. We studied the structural descriptors that contribute to the biological activity of substances. For a series of nine substances, results show that descriptors CSAA, CSEV and TFES appear to be responsible for the inhibitory activity of these substances.

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Published

2014-11-26

Issue

Section

Working Group 1: Plant Cultivation and Animal Growing Technologies