THE CORRELATION STUDIES OF ANTIMYCOBACTERIAL ACTIVITY FOR A NUMBER OF DERIVATIVES OF 4-CARBOXAMIDE

Authors

  • Emilia Amzoiu Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova
  • Larisa Elisabeth Averis Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova
  • Cornelia Bejenaru Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova
  • Manuel ovidiu Amzoiu Technical college "I.G. Murgulescu", Craiov
  • Paul Gabriel Anoaica Faculty of Medicine, University of Medicine and Pharmacy, Craiova

Abstract

In order to produce a desired physiological effect, substances have to cross cell membranes. The ability of a chemical compound to cross membranes is influenced primarily by the partition coefficient. This is a physical-chemical factor that directly influence the pharmacokinetic profile of the drug and indirect its pharmacodynamic profile. The paper is a QSAR study carried out on a class of substituted of carboxamide, having antimycobacterial activity against the atypical mycobacterial strains and that these compounds are inhibitors of the photosynthesis process. The purpose of such a study is to link the chemical structures of the compounds represented by a set of molecular descriptors with biological activity exhibited by them, expressed as IC50. Identifying these descriptors leads to information of the changes induced by  the presence and nature of different chemical groups in the molecule, which allows optimization of analyzed biological activity.

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Published

2014-11-26

Issue

Section

Working Group 1: Plant Cultivation and Animal Growing Technologies